a b.ubbling gee.k.s

Interaction between RasV12 and scribbled clones induces tumour growth and invasion Nature advance online publication 13 January 2010. doi:10.1038/nature08702 Authors: Ming Wu, Jos? Carlos Pastor-Pareja & Tian Xu Human tumours have a large degree of cellular and genetic heterogeneity. Complex cell interactions in the tumour and its microenvironment are thought to have an important role in tumorigenesis and cancer progression. Furthermore, cooperation between oncogenic genetic lesions is required for tumour development; however, it is not known how cell interactions contribute to oncogenic cooperation. The genetic techniques available in the fruitfly Drosophila melanogaster allow analysis of the behaviour of cells with distinct mutations, making this the ideal model organism with which to study cell interactions and oncogenic cooperation. In Drosophila eye-antennal discs, cooperation between the oncogenic protein RasV12 (ref. 5) and loss-of-function…

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Interaction between RasV12 and scribbled clones induces tumour growth and invasion

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• Interaction between RasV12 and scribbled clones induces tumour growth and invasion